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Condition Path

Treatment-Resistant Depression

Layered ketamine protocols, integrative psychotherapy, and precision nutrition unlock remission for patients who have cycled through traditional antidepressants.

Signals we assess

Clinical indicators we measure at intake

Klarity’s intake consult benchmarks treatment-resistant depression biomarkers, mood-tracking patterns, cognitive performance, and nervous system resilience. The result is a precision roadmap that prioritizes regulation before any infusion or neuromodulation begins.

  • Persistent low mood or anhedonia despite multiple medication trials
  • High-functioning professionals masking severe internal depression
  • Patients transitioning out of inpatient or PHP/IOP programs

Personalized protocols

How our team delivers regenerative treatment-resistant depression treatment

Your integrated care team pairs our ketamine-enhanced therapy with stellate ganglion blocks (if appropriate, currently available in Upland only), neuromodulation, nutrient optimization, and hospitality-level recovery spaces. The plan flexes around real-time data so the protocol stays aligned with your goals.

  • Rapid-acting IV ketamine series calibrated with mood telemetry
  • Medication reconciliation with psychotherapy and mind-body integration
  • Lifestyle redesign and concierge follow-up for sustainable change

Integration & outcomes

Sustained gains beyond the infusion chair

Klarity tracks every phase of your treatment-resistant depression progress with validated assessments, biometric feedback, and a curated integration playbook. Expect concierge check-ins, habit scaffolding, and cross-talk with your existing providers to keep breakthroughs anchored.

Outcome focus: Avg. 75% reduction in PHQ-9 scores across the first six infusions Keyword: treatment-resistant depression ketamine therapy